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After a decade of protocol development and preparations, MultiPark researchers have finally launched the clinical trial. Recently, dopamine-producing cells generated from embryonic stem cells were transplanted into the first Parkinson's patient at Skåne University Hospital. During the autumn 2022, the Swedish MPA (Läkemedelsverket) approved the clinical STEM-PD study. Several of MultiParks PIs hav

https://www.multipark.lu.se/article/stem-pd-bench-bedside-story-multipark-researchers-0 - 2025-09-29

Looking for the next step in your career? In need of some scientific inspiration? Or are you just curious about what MultiPark´s senior researchers are doing and their professional journey? Listen to MultiPark’s new podcast series “Meet our scientists”! In a newly launched podcast, young MultiPark researchers interview our research group leaders about their academic journey and main scientific foc

https://www.multipark.lu.se/article/meet-our-scientists-new-podcast-young-multipark-researchers - 2025-09-29

In the early 1950s, no one knew what caused Parkinson's disease. Then, Arvid Carlsson's discovery of dopamine opened the door to world-leading transplantations for Parkinson's patients. Thanks to the pioneering basic research at MultiPark, stemcell-derived neural cells can now be tested in a clinical trial for the first time. In Parkinson's disease, the nerve cells in an area of the brain that con

https://www.multipark.lu.se/article/world-parkinsons-day-transplantations-parkinsons-disease-time-travel - 2025-09-29

Genetics are one of the keys to understanding neurodegenerative disease. That is why MultiPark researchers with expertise in genetics gather across research groups. Genetics of neurodegenerative diseases is a new special interest group (SIG) addressing scientific and technological needs to unravel the genetics behind diseases such as Parkinson’s and Alzheimer’s. Andreas Puschmann tells about how h

https://www.multipark.lu.se/article/genetics-neurodegenerative-diseases-special-interest-group - 2025-09-29

Three researchers at Lund University, all with a long list of significant research credentials, have been awarded the ERC Advanced Grant worth EUR 2.5 million each to further develop and advance their research projects. Two of them are MultiPark research leaders. They do research on chaperone proteins’ function in neurodegenerative diseases and blood tests for rapid screening of drugs in the treat

https://www.multipark.lu.se/article/double-success-multipark-research-groups-prestigious-eu-grant-round - 2025-09-29

Several Nobel laureates, renowned scientists, and successful biotech entrepreneurs are coming to Lund in May to participate in the Lund Spring Symposium, an international pharmaceutical symposium sponsored by MultiPark. Sarah Tabrizi, a high profile Huntington researcher, and some of MultiPark's own researchers will speak. Medications are the physician's primary tool when treating their patients,

https://www.multipark.lu.se/article/superstars-coming-lund-pharmaceutical-symposium-sponsored-multipark - 2025-09-29

A research group from Lund Stem Cell Center aims to understand a specific type of neuron that could underlie several brain disorders including schizophrenia, epilepsy and autism, and are developing exciting new strategies to treat them. Read the full article here.

https://www.multipark.lu.se/article/restoring-neural-networks-and-understanding-brain-disorders - 2025-09-29

Researchers at Lund University in Sweden believe they have identified a gene variant that can cause cerebral small vessel disease and stroke. The study is published in Neurology Genetics. Read more about this discovery.  Article in Neurology Genetics MAP3K6 Mutations in a Neurovascular Disease Causing Stroke, Cognitive Impairment, and Tremor (Neurology Genetics, February 2021)

https://www.multipark.lu.se/article/new-gene-variant-linked-stroke - 2025-09-29

Overexpression of the Parkinson-related protein, α-synuclein, leads to blood-brain barrier leakage and pericyte activation in mice. A study published in Scientific Reports identifies pericytes as potential target cells for early interventions. Parkinson’s disease is a movement disorder caused by the accumulation and aggregation of α-synuclein and degeneration of dopaminergic neurons. Disruption of

https://www.multipark.lu.se/article/pericytes-link-between-parkinson-related-protein-and-blood-brain-barrier-disruption - 2025-09-29

Researchers from Lund Stem Cell Center highlight the importance of controlling viral elements that reside in the genome and how their activation during development may contribute to brain disorders later in life. Around 10% of the human genome is composed of DNA sequences originating from viruses that infected our ancestors throughout the millions of years of our evolution. Under normal conditions

https://www.multipark.lu.se/article/activation-ancient-viruses-during-brain-development-causes-inflammation - 2025-09-29

During her PhD studies Shelby Shrigley has been exploring patient-specific cell replacement therapy for Parkinson's disease. Defending her PhD thesis on March 12th, here Shelby tells us about her research within the Developmental and Regenerative Neurobiology research group led by Prof. Malin Parmar and her time spent at Lund Stem Cell Center. Can you tell us about your PhD research? The main focu

https://www.multipark.lu.se/article/phd-defence-interview-shelby-shrigley - 2025-09-29

Alzheimer’s disease seems to progress faster in women than in men. The protein tau accumulates at a higher rate in women, according to research from Lund University in Sweden. The study was recently published in Brain. Over 30 million people suffer from Alzheimer’s disease worldwide, making it the most common form of dementia. Tau and beta-amyloid are two proteins known to aggregate and accumulate

https://www.multipark.lu.se/article/women-accumulate-alzheimers-related-protein-faster - 2025-09-29

In a collaborative study, with other European research groups, scientists from Lund University in Sweden have shed new light on how the protein aggregates that accumulate in the Parkinsonian brain may contribute to neuronal injury during disease progression. The study is published in Cell Reports. The brain is a complex organ composed of billions of neurons, whose proper function is dependent on a

https://www.multipark.lu.se/article/new-insights-toxic-protein-aggregate-formation-parkinsons-disease-size-matters - 2025-09-29

On the last of December, Professor Gunnar Gouras left his position as a coordinator for MultiPark after five years. Here is how he sums up his time and mission for our environment. Can you describe your time as a coordinator for Multipark? To lead Multipark has been very interesting as well as challenging. To have the support from the Swedish government to invest in excellent research is fantastic

https://www.multipark.lu.se/article/interview-gunnar-gouras-about-his-time-coordinator - 2025-09-29

Congratulations to Prof. Malin Parmar, who has been elected as one of three new members of the Board of Directors at the International Society for Stem Cell Research (ISSCR). The Developmental and Regenerative Neurobiology research group led by Prof. Parmar aims to develop new, cell-based therapies for neurodegenerative diseases. Together with her team, Prof. Parmar has shown in a series of pionee

https://www.multipark.lu.se/article/malin-parmar-elected-isscr-board-directors - 2025-09-29

Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in Nature Medicine. “In contrast to how we have so far interpreted the spread of tau in the

https://www.multipark.lu.se/article/alzheimers-disease-composed-four-distinct-subtypes - 2025-09-29

On May 11, it is time for the first of a total of six workshops concerning the strategic research areas’ (SRA) work on sustainable development. Sustainability is more than climate and environmental issues. Goal number 3 of the UN global sustainability goals focuses on “good health and well-being”. The workshop series are arranged by the SRA Collegium and Sustainability forum. Within the health-rel

https://www.multipark.lu.se/article/workshop-series-sustainability-effect-research - 2025-09-29

Deep interviews with patients who are at an early stage of Parkinson’s disease show that acceptance was a prerequisite for a maintained life satisfaction despite the disease. The study was conducted by health science researchers from the strategic research area MultiPark at Lund University. People living with Parkinson's disease deal with symptoms and impairments due to the progression of the dise

https://www.multipark.lu.se/article/acceptance-key-life-satisfaction-persons-parkinsons-disease - 2025-09-29

Nine senior researchers from five different faculties at Lund University have been granted three million SEK for a novel transdisciplinary initiative to improve the early diagnosis of Alzheimer’s disease. Four of them are research leaders from the strategic research area MultiPark at the Medical Faculty. The collaboration also involves Region Skåne, Lund Municipality, and several important partner

https://www.multipark.lu.se/article/three-million-new-thematic-collaboration-initiative-about-early-diagnosis-and-prognostics-alzheimers - 2025-09-29

Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer's disease in the future. The findings are published in Nature Medicine. Approximately 20-30% of patients with Alzheimer's disease are wrongly diagnosed within specialist healthcare, and diagnostic work-up

https://www.multipark.lu.se/article/simple-diagnostic-tool-predicts-individual-risk-alzheimers - 2025-09-29